Specific Membrane Binding of Neurotoxin II Can Facilitate Its Delivery to Acetylcholine Receptor

The action of three-finger snake α-neurotoxins at their targets, nicotinic acetylcholine receptors (nAChR), is widely studied because of its biological and pharmacological relevance. Most such studies deal only with ligands and receptor models; however, for many ligand/receptor systems the membrane...

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Veröffentlicht in:	Biophysical journal 2009-10, Vol.97 (7), p.2089-2097
Hauptverfasser:	Lesovoy, Dmitry M., Bocharov, Eduard V., Lyukmanova, Ekaterina N., Kosinsky, Yurij A., Shulepko, Mikhail A., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P., Efremov, Roman G., Arseniev, Alexander S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biomimetics Biophysics Cell Membrane - chemistry Cell Membrane - metabolism Elapidae Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipids Liposomes - chemistry Liposomes - metabolism Magnetic Resonance Spectroscopy Membranes Models, Molecular Molecular Sequence Data Molecules Mutagenesis Mutation Naja oxiana Neurotoxicity Neurotoxins - chemistry Neurotoxins - genetics Neurotoxins - metabolism Protein Protein Conformation Receptors, Cholinergic - metabolism Simulation Substrate Specificity Surface Properties T cell receptors Torpedo Toxins
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