A locus on distal chromosome 10 ( ahl4 ) affecting age-related hearing loss in A/J mice

Abstract The ahl locus, shown to be a strain-specific Cdh23 dimorphism, contributes to age-related hearing loss in many inbred mouse strains. A/J mice begin to lose hearing by 4 weeks of age, much earlier than C57BL/6J (B6) mice, although both strains have the same Cdh23 ahl variant. Here, we use re...

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Veröffentlicht in:	Neurobiology of aging 2009-10, Vol.30 (10), p.1693-1705
Hauptverfasser:	Zheng, Qing Yin, Ding, Dalian, Yu, Heping, Salvi, Richard J, Johnson, Kenneth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Animals Biological and medical sciences Cadherins - genetics Chromosomes, Mammalian Cochlea - pathology Cochlea - physiopathology Deafness Development. Senescence. Regeneration. Transplantation Disease Progression Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Female Fundamental and applied biological sciences. Psychology Genetic mapping Hair Cells, Auditory, Inner - pathology Hair Cells, Auditory, Inner - physiology Hair Cells, Auditory, Outer - pathology Hair Cells, Auditory, Outer - physiology Hair Cells, Vestibular - pathology Hair Cells, Vestibular - physiology Hearing Loss - genetics Hearing Loss - pathology Hearing Loss - physiopathology Inbred strain Internal Medicine Male Mice Mice, Inbred A Mice, Inbred C57BL Mouse Neurology Neurons - pathology Neurons - physiology Polymorphism, Genetic Presbycusis Species Specificity Spiral Ganglion - pathology Spiral Ganglion - physiopathology Stria Vascularis - pathology Stria Vascularis - physiology Vertebrates: nervous system and sense organs
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