MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy

Loss of PTEN and activation of PI3K are commonly observed in advanced prostate cancer. Inhibition of mTOR, a downstream target of PI3K signaling, results in cell cycle arrest and apoptosis in multiple in vitro and in vivo models of prostate cancer. However, single agent use of mTOR inhibition has li...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-09, Vol.69 (19), p.7803-7810
Hauptverfasser:	Balakumaran, Bala S., Porrello, Alessandro, Hsu, David S., Glover, Wayne, Foye, Adam, Leung, Janet Y., Sullivan, Beth A., Hahn, William C., Loda, Massimo, Febbo, Phillip G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!