Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions

In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesis. In this study, we report a detailed kinetic analysis of the human and yeast CBS-catalyzed reacti...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (33), p.22457-22466
Hauptverfasser:	Singh, Sangita, Padovani, Dominique, Leslie, Rachel A., Chiku, Taurai, Banerjee, Ruma
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemistry Chromatography, High Pressure Liquid Computer Simulation Cystathionine beta-Synthase - chemistry Cystathionine gamma-Lyase - chemistry Cysteine - chemistry Enzyme Catalysis and Regulation Humans Hydrogen Sulfide - chemistry Kinetics Mass Spectrometry - methods Models, Biological Models, Chemical Molecular Conformation Serine - chemistry Sulfides - chemistry Sulfur - chemistry
Online-Zugang:	Volltext
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