Transforming Growth Factor-β (TGF-β1) Activates TAK1 via TAB1-mediated Autophosphorylation, Independent of TGF-β Receptor Kinase Activity in Mesangial Cells

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that signals through the interaction of type I (TβRI) and type II (TβRII) receptors to activate distinct intracellular pathways. TAK1 is a serine/threonine kinase that is rapidly activated by TGF-β1. However, the molecular mechanis...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (33), p.22285-22296
Hauptverfasser:	Kim, Sung Il, Kwak, Joon Hyeok, Na, Hee-Jun, Kim, Jin Kuk, Ding, Yan, Choi, Mary E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Gene Deletion Gene Expression Regulation Ligands Male MAP Kinase Kinase Kinases - metabolism Mechanisms of Signal Transduction Mesangial Cells - metabolism Mice Mice, Inbred C57BL Models, Biological Models, Genetic Phosphorylation Protein-Serine-Threonine Kinases - metabolism Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta - metabolism Transforming Growth Factor beta1 - metabolism
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