Oligomeric Yeast Frataxin Drives Assembly of Core Machinery for Mitochondrial Iron-Sulfur Cluster Synthesis

Mitochondrial biosynthesis of iron-sulfur clusters (ISCs) is a vital process involving the delivery of elemental iron and sulfur to a scaffold protein via molecular interactions that are still poorly defined. Analysis of highly conserved components of the yeast ISC assembly machinery shows that the...

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Veröffentlicht in:The Journal of biological chemistry 2009-08, Vol.284 (33), p.21971-21980
Hauptverfasser: Li, Hongqiao, Gakh, Oleksandr, Smith, Douglas Y., Isaya, Grazia
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Sprache:eng
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