Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain

Macrophages detect pathogen infection via the activation of their plasma membrane-bound Toll-like receptor proteins (TLRs). The heterotypic interaction between the Toll/interleukin-1 receptor (TIR) domains of TLRs and adaptor proteins, like Myeloid differentiation primary response gene 88 (MyD88), i...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (32), p.21386-21392
Hauptverfasser:	Chan, Siew Leong, Low, Lieh Yoon, Hsu, Simon, Li, Sheng, Liu, Tong, Santelli, Eugenio, Le Negrate, Gaelle, Reed, John C, Woods, Jr, Virgil L, Pascual, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Crystallography, X-Ray - methods Cytokines - metabolism Dimerization Escherichia coli - metabolism Humans Immunoprecipitation Inflammation Models, Biological Models, Molecular Molecular Conformation Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - physiology Paracoccus denitrificans - metabolism Protein Structure and Folding Protein Structure, Tertiary Toll-Like Receptors - chemistry
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