Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.Data sources We searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles....
Gespeichert in:
| Veröffentlicht in: | BMJ 2009-10, Vol.339 (7725), p.843-846 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 846 |
|---|---|
| container_issue | 7725 |
| container_start_page | 843 |
| container_title | BMJ |
| container_volume | 339 |
| creator | Bischoff-Ferrari, H A Dawson-Hughes, B Staehelin, H B Orav, J E Stuck, A E Theiler, R Wong, J B Egli, A Kiel, D P Henschkowski, J |
| description | Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.Data sources We searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles. Further studies were identified by consulting clinical experts, bibliographies, and abstracts. We contacted authors for additional data when necessary.Review methods Only double blind randomised controlled trials of older individuals (mean age 65 years or older) receiving a defined oral dose of supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol)) or an active form of vitamin D (1α-hydroxyvitamin D3 (1α-hydroxycalciferol) or 1,25-dihydroxyvitamin D3 (1,25-dihydroxycholecalciferol)) and with sufficiently specified fall assessment were considered for inclusion. Results Eight randomised controlled trials (n=2426) of supplemental vitamin D met our inclusion criteria. Heterogeneity among trials was observed for dose of vitamin D (700-1000 IU/day v 200-600 IU/day; P=0.02) and achieved 25-hydroxyvitamin D3 concentration (25(OH)D concentration: |
| doi_str_mv | 10.1136/bmj.b3692 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2755728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25672889</jstor_id><sourcerecordid>25672889</sourcerecordid><originalsourceid>FETCH-LOGICAL-b553t-e9ef31b10b37f38c6591266137f1c9bb0caf3614607c09ab7dbe3c3a57857e493</originalsourceid><addsrcrecordid>eNqFkktv1DAUhS0EoqPSBT8AZAkEYpFi58Z2zAIJBYYiVbCBip3lZBzqwYlT2xnov8fTGQ0PCVj5cT5f3XN8EbpPySmlwJ-3w_q0BS7LW2hBK14XrAa4jRZEMlnUFOojdBLjmhBSgqglZ3fREZVCCqjKBZqW2jk8BbMxY7J-xN9susRxniZnhnylHdbjCusu2Y3BvQ9DxL7HG5v0YEf8-gXWeDBJF3rU7jraGzXkJ36w0axw58cUvHN5m4LVLt5Dd_q8mJP9eow-Ld98bM6K8w9v3zWvzouWMUiFkaYH2lLSguih7jiTtOSc5hPtZNuSTvfAs18iOiJ1K1atgQ40EzUTppJwjF7u6k5zO5hVl70E7dQU7KDDtfLaqt-V0V6qL36jSsGYKOtc4Om-QPBXs4lJZUedcU6Pxs9RCV6BLCtRZvLJP0kuuKiAi_-CTADQUlYZfPQHuPZzyAlHRYWoSf5uSTL1bEd1wccYTH9wR4nazobKs6FuZiOzD3-N4ye5n4QMPNgB65h8OOgl4zmMeptnsdNtTOb7Qdfha_YHgqn3F406A_jcXJClajL_eMdve_h7Xz8A4x_aUg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1778036990</pqid></control><display><type>article</type><title>Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Bischoff-Ferrari, H A ; Dawson-Hughes, B ; Staehelin, H B ; Orav, J E ; Stuck, A E ; Theiler, R ; Wong, J B ; Egli, A ; Kiel, D P ; Henschkowski, J</creator><creatorcontrib>Bischoff-Ferrari, H A ; Dawson-Hughes, B ; Staehelin, H B ; Orav, J E ; Stuck, A E ; Theiler, R ; Wong, J B ; Egli, A ; Kiel, D P ; Henschkowski, J</creatorcontrib><description>Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.Data sources We searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles. Further studies were identified by consulting clinical experts, bibliographies, and abstracts. We contacted authors for additional data when necessary.Review methods Only double blind randomised controlled trials of older individuals (mean age 65 years or older) receiving a defined oral dose of supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol)) or an active form of vitamin D (1α-hydroxyvitamin D3 (1α-hydroxycalciferol) or 1,25-dihydroxyvitamin D3 (1,25-dihydroxycholecalciferol)) and with sufficiently specified fall assessment were considered for inclusion. Results Eight randomised controlled trials (n=2426) of supplemental vitamin D met our inclusion criteria. Heterogeneity among trials was observed for dose of vitamin D (700-1000 IU/day v 200-600 IU/day; P=0.02) and achieved 25-hydroxyvitamin D3 concentration (25(OH)D concentration: <60 nmol/l v ≥60 nmol/l; P=0.005). High dose supplemental vitamin D reduced fall risk by 19% (pooled relative risk (RR) 0.81, 95% CI 0.71 to 0.92; n=1921 from seven trials), whereas achieved serum 25(OH)D concentrations of 60 nmol/l or more resulted in a 23% fall reduction (pooled RR 0.77, 95% CI 0.65 to 0.90). Falls were not notably reduced by low dose supplemental vitamin D (pooled RR 1.10, 95% CI 0.89 to 1.35; n=505 from two trials) or by achieved serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l (pooled RR 1.35, 95% CI 0.98 to 1.84). Two randomised controlled trials (n=624) of active forms of vitamin D met our inclusion criteria. Active forms of vitamin D reduced fall risk by 22% (pooled RR 0.78, 95% CI 0.64 to 0.94).Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.</description><identifier>ISSN: 0959-8138</identifier><identifier>ISSN: 0959-535X</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.b3692</identifier><identifier>PMID: 19797342</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Accidental Falls - prevention & control ; Administration, Oral ; Aged ; Aged, 80 and over ; Authors ; Beef ; Bias ; Bone Density Conservation Agents - administration & dosage ; Bone fractures ; Calcium ; Calcium - administration & dosage ; Cholecalciferols ; Clinical Trials (Epidemiology) ; Design analysis ; Dietary Supplements ; Dosage ; Experimentation ; Falls ; Female ; Humans ; Internet ; Male ; Meta analysis ; Older adults ; Older people ; Prevention ; Randomized Controlled Trials as Topic ; Risk Factors ; Risk reduction ; Serum ; Studies ; Vitamin D ; Vitamin D - administration & dosage ; Vitamins</subject><ispartof>BMJ, 2009-10, Vol.339 (7725), p.843-846</ispartof><rights>2009 BMJ Publishing Group Ltd</rights><rights>Copyright BMJ Publishing Group LTD Oct 1, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b553t-e9ef31b10b37f38c6591266137f1c9bb0caf3614607c09ab7dbe3c3a57857e493</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmj.com/content/339/bmj.b3692.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmj.com/content/339/bmj.b3692.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,776,780,799,881,3183,23550,27901,27902,30977,57992,58225,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19797342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bischoff-Ferrari, H A</creatorcontrib><creatorcontrib>Dawson-Hughes, B</creatorcontrib><creatorcontrib>Staehelin, H B</creatorcontrib><creatorcontrib>Orav, J E</creatorcontrib><creatorcontrib>Stuck, A E</creatorcontrib><creatorcontrib>Theiler, R</creatorcontrib><creatorcontrib>Wong, J B</creatorcontrib><creatorcontrib>Egli, A</creatorcontrib><creatorcontrib>Kiel, D P</creatorcontrib><creatorcontrib>Henschkowski, J</creatorcontrib><title>Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.Data sources We searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles. Further studies were identified by consulting clinical experts, bibliographies, and abstracts. We contacted authors for additional data when necessary.Review methods Only double blind randomised controlled trials of older individuals (mean age 65 years or older) receiving a defined oral dose of supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol)) or an active form of vitamin D (1α-hydroxyvitamin D3 (1α-hydroxycalciferol) or 1,25-dihydroxyvitamin D3 (1,25-dihydroxycholecalciferol)) and with sufficiently specified fall assessment were considered for inclusion. Results Eight randomised controlled trials (n=2426) of supplemental vitamin D met our inclusion criteria. Heterogeneity among trials was observed for dose of vitamin D (700-1000 IU/day v 200-600 IU/day; P=0.02) and achieved 25-hydroxyvitamin D3 concentration (25(OH)D concentration: <60 nmol/l v ≥60 nmol/l; P=0.005). High dose supplemental vitamin D reduced fall risk by 19% (pooled relative risk (RR) 0.81, 95% CI 0.71 to 0.92; n=1921 from seven trials), whereas achieved serum 25(OH)D concentrations of 60 nmol/l or more resulted in a 23% fall reduction (pooled RR 0.77, 95% CI 0.65 to 0.90). Falls were not notably reduced by low dose supplemental vitamin D (pooled RR 1.10, 95% CI 0.89 to 1.35; n=505 from two trials) or by achieved serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l (pooled RR 1.35, 95% CI 0.98 to 1.84). Two randomised controlled trials (n=624) of active forms of vitamin D met our inclusion criteria. Active forms of vitamin D reduced fall risk by 22% (pooled RR 0.78, 95% CI 0.64 to 0.94).Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.</description><subject>Accidental Falls - prevention & control</subject><subject>Administration, Oral</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Authors</subject><subject>Beef</subject><subject>Bias</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Bone fractures</subject><subject>Calcium</subject><subject>Calcium - administration & dosage</subject><subject>Cholecalciferols</subject><subject>Clinical Trials (Epidemiology)</subject><subject>Design analysis</subject><subject>Dietary Supplements</subject><subject>Dosage</subject><subject>Experimentation</subject><subject>Falls</subject><subject>Female</subject><subject>Humans</subject><subject>Internet</subject><subject>Male</subject><subject>Meta analysis</subject><subject>Older adults</subject><subject>Older people</subject><subject>Prevention</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Factors</subject><subject>Risk reduction</subject><subject>Serum</subject><subject>Studies</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamins</subject><issn>0959-8138</issn><issn>0959-535X</issn><issn>1468-5833</issn><issn>1756-1833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkktv1DAUhS0EoqPSBT8AZAkEYpFi58Z2zAIJBYYiVbCBip3lZBzqwYlT2xnov8fTGQ0PCVj5cT5f3XN8EbpPySmlwJ-3w_q0BS7LW2hBK14XrAa4jRZEMlnUFOojdBLjmhBSgqglZ3fREZVCCqjKBZqW2jk8BbMxY7J-xN9susRxniZnhnylHdbjCusu2Y3BvQ9DxL7HG5v0YEf8-gXWeDBJF3rU7jraGzXkJ36w0axw58cUvHN5m4LVLt5Dd_q8mJP9eow-Ld98bM6K8w9v3zWvzouWMUiFkaYH2lLSguih7jiTtOSc5hPtZNuSTvfAs18iOiJ1K1atgQ40EzUTppJwjF7u6k5zO5hVl70E7dQU7KDDtfLaqt-V0V6qL36jSsGYKOtc4Om-QPBXs4lJZUedcU6Pxs9RCV6BLCtRZvLJP0kuuKiAi_-CTADQUlYZfPQHuPZzyAlHRYWoSf5uSTL1bEd1wccYTH9wR4nazobKs6FuZiOzD3-N4ye5n4QMPNgB65h8OOgl4zmMeptnsdNtTOb7Qdfha_YHgqn3F406A_jcXJClajL_eMdve_h7Xz8A4x_aUg</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Bischoff-Ferrari, H A</creator><creator>Dawson-Hughes, B</creator><creator>Staehelin, H B</creator><creator>Orav, J E</creator><creator>Stuck, A E</creator><creator>Theiler, R</creator><creator>Wong, J B</creator><creator>Egli, A</creator><creator>Kiel, D P</creator><creator>Henschkowski, J</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group Ltd</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QJ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091001</creationdate><title>Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials</title><author>Bischoff-Ferrari, H A ; Dawson-Hughes, B ; Staehelin, H B ; Orav, J E ; Stuck, A E ; Theiler, R ; Wong, J B ; Egli, A ; Kiel, D P ; Henschkowski, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b553t-e9ef31b10b37f38c6591266137f1c9bb0caf3614607c09ab7dbe3c3a57857e493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Accidental Falls - prevention & control</topic><topic>Administration, Oral</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Authors</topic><topic>Beef</topic><topic>Bias</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Bone fractures</topic><topic>Calcium</topic><topic>Calcium - administration & dosage</topic><topic>Cholecalciferols</topic><topic>Clinical Trials (Epidemiology)</topic><topic>Design analysis</topic><topic>Dietary Supplements</topic><topic>Dosage</topic><topic>Experimentation</topic><topic>Falls</topic><topic>Female</topic><topic>Humans</topic><topic>Internet</topic><topic>Male</topic><topic>Meta analysis</topic><topic>Older adults</topic><topic>Older people</topic><topic>Prevention</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Factors</topic><topic>Risk reduction</topic><topic>Serum</topic><topic>Studies</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bischoff-Ferrari, H A</creatorcontrib><creatorcontrib>Dawson-Hughes, B</creatorcontrib><creatorcontrib>Staehelin, H B</creatorcontrib><creatorcontrib>Orav, J E</creatorcontrib><creatorcontrib>Stuck, A E</creatorcontrib><creatorcontrib>Theiler, R</creatorcontrib><creatorcontrib>Wong, J B</creatorcontrib><creatorcontrib>Egli, A</creatorcontrib><creatorcontrib>Kiel, D P</creatorcontrib><creatorcontrib>Henschkowski, J</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bischoff-Ferrari, H A</au><au>Dawson-Hughes, B</au><au>Staehelin, H B</au><au>Orav, J E</au><au>Stuck, A E</au><au>Theiler, R</au><au>Wong, J B</au><au>Egli, A</au><au>Kiel, D P</au><au>Henschkowski, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>339</volume><issue>7725</issue><spage>843</spage><epage>846</epage><pages>843-846</pages><issn>0959-8138</issn><issn>0959-535X</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><coden>BMJOAE</coden><abstract>Objective To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.Data sources We searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles. Further studies were identified by consulting clinical experts, bibliographies, and abstracts. We contacted authors for additional data when necessary.Review methods Only double blind randomised controlled trials of older individuals (mean age 65 years or older) receiving a defined oral dose of supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol)) or an active form of vitamin D (1α-hydroxyvitamin D3 (1α-hydroxycalciferol) or 1,25-dihydroxyvitamin D3 (1,25-dihydroxycholecalciferol)) and with sufficiently specified fall assessment were considered for inclusion. Results Eight randomised controlled trials (n=2426) of supplemental vitamin D met our inclusion criteria. Heterogeneity among trials was observed for dose of vitamin D (700-1000 IU/day v 200-600 IU/day; P=0.02) and achieved 25-hydroxyvitamin D3 concentration (25(OH)D concentration: <60 nmol/l v ≥60 nmol/l; P=0.005). High dose supplemental vitamin D reduced fall risk by 19% (pooled relative risk (RR) 0.81, 95% CI 0.71 to 0.92; n=1921 from seven trials), whereas achieved serum 25(OH)D concentrations of 60 nmol/l or more resulted in a 23% fall reduction (pooled RR 0.77, 95% CI 0.65 to 0.90). Falls were not notably reduced by low dose supplemental vitamin D (pooled RR 1.10, 95% CI 0.89 to 1.35; n=505 from two trials) or by achieved serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l (pooled RR 1.35, 95% CI 0.98 to 1.84). Two randomised controlled trials (n=624) of active forms of vitamin D met our inclusion criteria. Active forms of vitamin D reduced fall risk by 22% (pooled RR 0.78, 95% CI 0.64 to 0.94).Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>19797342</pmid><doi>10.1136/bmj.b3692</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8138 |
| ispartof | BMJ, 2009-10, Vol.339 (7725), p.843-846 |
| issn | 0959-8138 0959-535X 1468-5833 1756-1833 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2755728 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy; MEDLINE; BMJ Journals - NESLi2 |
| subjects | Accidental Falls - prevention & control Administration, Oral Aged Aged, 80 and over Authors Beef Bias Bone Density Conservation Agents - administration & dosage Bone fractures Calcium Calcium - administration & dosage Cholecalciferols Clinical Trials (Epidemiology) Design analysis Dietary Supplements Dosage Experimentation Falls Female Humans Internet Male Meta analysis Older adults Older people Prevention Randomized Controlled Trials as Topic Risk Factors Risk reduction Serum Studies Vitamin D Vitamin D - administration & dosage Vitamins |
| title | Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T16%3A59%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fall%20prevention%20with%20supplemental%20and%20active%20forms%20of%20vitamin%20D:%20a%20meta-analysis%20of%20randomised%20controlled%20trials&rft.jtitle=BMJ&rft.au=Bischoff-Ferrari,%20H%20A&rft.date=2009-10-01&rft.volume=339&rft.issue=7725&rft.spage=843&rft.epage=846&rft.pages=843-846&rft.issn=0959-8138&rft.eissn=1468-5833&rft.coden=BMJOAE&rft_id=info:doi/10.1136/bmj.b3692&rft_dat=%3Cjstor_pubme%3E25672889%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1778036990&rft_id=info:pmid/19797342&rft_jstor_id=25672889&rfr_iscdi=true |