Characterization of Wise Protein and Its Molecular Mechanism to Interact with both Wnt and BMP Signals

Cross-talk of BMP and Wnt signaling pathways has been implicated in many aspects of biological events during embryogenesis and in adulthood. A secreted protein Wise and its orthologs (Sostdc1, USAG-1, and Ectodin) have been shown to modulate Wnt signaling and also inhibit BMP signals. Modulation of...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (34), p.23159-23168
Hauptverfasser:	Lintern, Katherine B., Guidato, Sonia, Rowe, Alison, Saldanha, José W., Itasaki, Nobue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Proteins - chemistry Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Line Chickens Glycosylation Humans Immunoprecipitation LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - metabolism Mechanisms of Signal Transduction Mice Models, Molecular Mutation Protein Binding Protein Structure, Tertiary Proteoglycans - metabolism Signal Transduction Wnt Proteins - genetics Wnt Proteins - metabolism
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