Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA

Helicobacter pylori CagA plays a key role in gastric carcinogenesis. Upon delivery into gastric epithelial cells, CagA binds and deregulates SHP-2 phosphatase, a bona fide oncoprotein, thereby causing sustained ERK activation and impaired focal adhesions. CagA also binds and inhibits PAR1b/MARK2, on...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (34), p.23024-23036
Hauptverfasser:	Lu, Huaisheng, Murata-Kamiya, Naoko, Saito, Yasuhiro, Hatakeyama, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Cell Line Cell Polarity - genetics Cell Polarity - physiology Chlorocebus aethiops COS Cells Dogs Electrophoresis, Polyacrylamide Gel Humans Immunoblotting Immunoprecipitation Mechanisms of Signal Transduction Protein Binding Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology RNA Interference Tight Junctions - metabolism
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