Angiopoietin 2 Mediates the Differentiation and Migration of Neural Progenitor Cells in the Subventricular Zone after Stroke

Ischemic stroke stimulates neurogenesis in the adult rodent brain. The molecules underlying stroke-induced neurogenesis have not been fully investigated. Using real-time reverse transcription-PCR, we found that stroke substantially up-regulated angiopoietin 2 (ANG2), a proangiogenic gene, expression...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (34), p.22680-22689
Hauptverfasser:	Liu, Xian Shuang, Chopp, Michael, Zhang, Rui Lan, Hozeska-Solgot, Ann, Gregg, Sara C., Buller, Ben, Lu, Mei, Zhang, Zheng Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin-2 - genetics Angiopoietin-2 - pharmacology Angiopoietin-2 - physiology Animals Brain - cytology Brain - drug effects Brain - metabolism Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Cells, Cultured Chromatin Immunoprecipitation Dipeptides - pharmacology Electroporation Gene Expression - drug effects Humans Immunohistochemistry In Vitro Techniques Male Mechanisms of Signal Transduction Metalloendopeptidases - antagonists & inhibitors Mice Microdissection Neurons - cytology Neurons - drug effects Neurons - metabolism Oligonucleotide Array Sequence Analysis Receptor, TIE-2 - genetics Receptor, TIE-2 - metabolism Receptor, TIE-2 - physiology Recombinant Proteins - genetics Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Stroke - physiopathology
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