PR55α, a Regulatory Subunit of PP2A, Specifically Regulates PP2A-mediated β-Catenin Dephosphorylation

A central question in Wnt signaling is the regulation of β-catenin phosphorylation and degradation. Multiple kinases, including CKIα and GSK3, are involved in β-catenin phosphorylation. Protein phosphatases such as PP2A and PP1 have been implicated in the regulation of β-catenin. However, which phos...

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Veröffentlicht in:	The Journal of biological chemistry 2009-08, Vol.284 (34), p.22649-22656
Hauptverfasser:	Zhang, Wen, Yang, Jun, Liu, Yajuan, Chen, Xi, Yu, Tianxin, Jia, Jianhang, Liu, Chunming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axin Protein beta Catenin - metabolism Blotting, Western Cell Line Cell Line, Tumor Drosophila melanogaster Enzyme Inhibitors - pharmacology Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Humans Immunoprecipitation Lithium Chloride - pharmacology Mechanisms of Signal Transduction Okadaic Acid - pharmacology Phosphorylation - drug effects Protein Binding Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Protein Subunits Pyrans - pharmacology Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Small Interfering Spiro Compounds - pharmacology
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