Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

Caspase-2 is an initiator caspase activated in response to heat shock and other stressors that induce apoptosis. Activation of caspase-2 requires induced proximity resulting after recruitment to caspase-2 activation complexes such as the PIDDosome. We have adapted bimolecular fluorescence complement...

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Veröffentlicht in:	Molecular cell 2009-09, Vol.35 (6), p.830-840
Hauptverfasser:	Bouchier-Hayes, Lisa, Oberst, Andrew, McStay, Gavin P., Connell, Samuel, Tait, Stephen W.G., Dillon, Christopher P., Flanagan, Jonathan M., Beere, Helen M., Green, Douglas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptotic Protease-Activating Factor 1 - metabolism Bacterial Proteins - genetics Biosensing Techniques Caspase 2 - genetics Caspase 2 - metabolism CELLCYCLE CRADD Signaling Adaptor Protein - metabolism Cytoplasm - enzymology DNA Damage DNA-Binding Proteins - metabolism Enzyme Activation Fas-Associated Death Domain Protein - metabolism Heat Shock Transcription Factors HeLa Cells Hot Temperature HSP90 Heat-Shock Proteins - metabolism Humans Kinetics Luminescent Proteins - genetics Mice Mice, Knockout Microscopy, Confocal Mitochondria - metabolism Mitochondria - pathology Mutagenesis, Site-Directed Protein Multimerization Recombinant Fusion Proteins - metabolism RNA Interference Signal Transduction Stress, Physiological Transcription Factors - metabolism Transfection Tubulin Modulators - pharmacology
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