Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin

We evaluated the potential of an injectable degradable polymer—poly(sebacic-co-ricinoleic-ester-anhydride) containing gentamicin for the treatment of osteomyelitis. Osteomyelitis of both tibiae was induced in 13 female Fischer rats by injecting a suspension containing approximately 105 (CFU)/ml of S...

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Veröffentlicht in:	Journal of controlled release 2008-10, Vol.131 (2), p.121-127
Hauptverfasser:	Brin, Yaron S., Golenser, Jacob, Mizrahi, Boaz, Maoz, Guy, Domb, Abraham J., Peddada, Shyamal, Tuvia, Shmuel, Nyska, Abraham, Nyska, Meir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biocompatible Materials - chemistry Biological and medical sciences Decanoic Acids - chemistry Delivery vehicle Disease Models, Animal Drug Carriers - chemistry Drug Compounding Female General pharmacology Gentamicin Gentamicins - administration & dosage Gentamicins - chemistry Gentamicins - pharmacokinetics Gentamicins - therapeutic use Injectable degradable polymer Injections, Intralesional Medical sciences Osteomyelitis Osteomyelitis - diagnostic imaging Osteomyelitis - drug therapy Osteomyelitis - pathology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(sebacic-co-ricinoleic-ester-anhydride) Polymers - chemistry Radiography Rats Rats, Inbred F344 Ricinoleic Acids - chemistry S. aureus Solubility Staphylococcal Infections - diagnostic imaging Staphylococcal Infections - drug therapy Staphylococcal Infections - pathology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Tibia - diagnostic imaging Tibia - microbiology Tibia - pathology
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