A role for c‐Myc in the regulation of ribosomal RNA processing

The proto‐oncogene c‐myc encodes a basic helix–loop–helix leucine zipper transcription factor (c‐Myc) that has a profound role in growth control and cell cycle progression. Previous microarray studies identified various classes of c‐Myc target genes, including genes involved in ribosome biogenesis....

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Veröffentlicht in:	Nucleic acids research 2003-11, Vol.31 (21), p.6148-6156
Hauptverfasser:	Schlosser, Isabel, Hölzel, Michael, Mürnseer, Marlies, Burtscher, Helmut, Weidle, Ulrich H., Eick, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes c-myc gene Cell Cycle Cell Line Cell Nucleolus - drug effects Cell Nucleolus - genetics Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Fibroblasts Humans Kinetics Mitogens - pharmacology Models, Genetic Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Purines - pharmacology Rats Ribosomes - drug effects Ribosomes - genetics Ribosomes - metabolism RNA Polymerase I - metabolism RNA Precursors - chemistry RNA Precursors - genetics RNA Precursors - metabolism RNA Processing, Post-Transcriptional - drug effects RNA, Ribosomal - biosynthesis RNA, Ribosomal - chemistry RNA, Ribosomal - genetics RNA, Ribosomal - metabolism RNA, Ribosomal, 18S - biosynthesis RNA, Ribosomal, 18S - chemistry RNA, Ribosomal, 18S - genetics RNA, Ribosomal, 18S - metabolism RNA, Ribosomal, 28S - biosynthesis RNA, Ribosomal, 28S - chemistry RNA, Ribosomal, 28S - genetics RNA, Ribosomal, 28S - metabolism Roscovitine Substrate Specificity Transcription, Genetic - genetics
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