Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain

Abstract Repeated exposure to sub-lethal insults has been reported to result in neuroprotection against a subsequent deleterious insult. The purpose of this study was to evaluate whether repeated exposure (preconditioning) to a non-5-HT depleting dose of MDMA in adult rats provides neuroprotection a...

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Veröffentlicht in:	Brain research 2009-08, Vol.1286, p.32-41
Hauptverfasser:	Bhide, Nirmal S, Lipton, Jack W, Cunningham, Jacobi I, Yamamoto, Bryan K, Gudelsky, Gary A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - pharmacology Animals Biological and medical sciences Blotting, Western Brain - drug effects Brain - metabolism Dopamine - metabolism Drug addictions Drug Tolerance - physiology Fever - chemically induced MDMA Medical sciences Methamphetamine - pharmacology N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurotoxicity Rats RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - drug effects Serotonin Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology Toxicology
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