Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities

The role of Th17 lymphocytes in immunopathogenic processes has been well established, but little is known about their basic cell features. In this study, we compared polarized Th1 and Th17 for key biological activities related to pathogenicity and trafficking. Th1 and Th17 lineages were derived from...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-06, Vol.180 (11), p.7414-7422
Hauptverfasser:	Cox, Catherine A, Shi, Guangpu, Yin, Hongen, Vistica, Barbara P, Wawrousek, Eric F, Chan, Chi-Chao, Gery, Igal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer ADP-ribosyl Cyclase 1 - immunology ADP-ribosyl Cyclase 1 - metabolism Animals Cell Line Cell Polarity Cells, Cultured Cytokines - analysis Cytokines - immunology Eye Diseases - immunology Eye Diseases - metabolism Eye Diseases - pathology Inflammation - immunology Inflammation - metabolism Inflammation - pathology Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-17 - immunology Interleukin-17 - metabolism Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Mutant Strains Mice, Transgenic Receptors, CXCR3 - immunology Receptors, CXCR3 - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Th1 Cells - immunology Th1 Cells - metabolism
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