Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-10, Vol.322 (5900), p.405-410
Hauptverfasser:	Roguev, Assen, Bandyopadhyay, Sourav, Zofall, Martin, Zhang, Ke, Fischer, Tamas, Collins, Sean R, Qu, Hongjing, Shales, Michael, Park, Han-Oh, Hayles, Jacqueline, Hoe, Kwang-Lae, Kim, Dong-Uk, Ideker, Trey, Grewal, Shiv I, Weissman, Jonathan S, Krogan, Nevan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological evolution Cellular biology Chromatin DNA DNA Repair DNA Replication Environmental conservation Epistasis, Genetic Evolutionary genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Gene Regulatory Networks Genes Genes, Fungal Genetics of eukaryotes. Biological and molecular evolution Genotype & phenotype Histones Histones - metabolism Human genetics Molecular biology Mutation Quantitative genetics Research Article RNA Interference Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomycetales Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Yeast Yeasts
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