Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast
An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2008-10, Vol.322 (5900), p.405-410 |
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| creator | Roguev, Assen Bandyopadhyay, Sourav Zofall, Martin Zhang, Ke Fischer, Tamas Collins, Sean R Qu, Hongjing Shales, Michael Park, Han-Oh Hayles, Jacqueline Hoe, Kwang-Lae Kim, Dong-Uk Ideker, Trey Grewal, Shiv I Weissman, Jonathan S Krogan, Nevan J |
| description | An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially. |
| doi_str_mv | 10.1126/science.1162609 |
| format | Article |
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This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1162609</identifier><identifier>PMID: 18818364</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Biological and medical sciences ; Biological evolution ; Cellular biology ; Chromatin ; DNA ; DNA Repair ; DNA Replication ; Environmental conservation ; Epistasis, Genetic ; Evolutionary genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Fungal ; Gene Regulatory Networks ; Genes ; Genes, Fungal ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype & phenotype ; Histones ; Histones - metabolism ; Human genetics ; Molecular biology ; Mutation ; Quantitative genetics ; Research Article ; RNA Interference ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomycetales ; Schizosaccharomyces - genetics ; Schizosaccharomyces - metabolism ; Schizosaccharomyces pombe Proteins - genetics ; Schizosaccharomyces pombe Proteins - metabolism ; Yeast ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5900), p.405-410</ispartof><rights>Copyright 2008 American Association for the Advancement of Science</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-f92f3f5c81273b5f228bce6c9f214e1d8e152ab76f7c130f4e5a4c8d8cf4940f3</citedby><cites>FETCH-LOGICAL-c622t-f92f3f5c81273b5f228bce6c9f214e1d8e152ab76f7c130f4e5a4c8d8cf4940f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20145055$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20145055$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20805705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18818364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roguev, Assen</creatorcontrib><creatorcontrib>Bandyopadhyay, Sourav</creatorcontrib><creatorcontrib>Zofall, Martin</creatorcontrib><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Fischer, Tamas</creatorcontrib><creatorcontrib>Collins, Sean R</creatorcontrib><creatorcontrib>Qu, Hongjing</creatorcontrib><creatorcontrib>Shales, Michael</creatorcontrib><creatorcontrib>Park, Han-Oh</creatorcontrib><creatorcontrib>Hayles, Jacqueline</creatorcontrib><creatorcontrib>Hoe, Kwang-Lae</creatorcontrib><creatorcontrib>Kim, Dong-Uk</creatorcontrib><creatorcontrib>Ideker, Trey</creatorcontrib><creatorcontrib>Grewal, Shiv I</creatorcontrib><creatorcontrib>Weissman, Jonathan S</creatorcontrib><creatorcontrib>Krogan, Nevan J</creatorcontrib><title>Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>An epistasis map (E-MAP) was constructed in the fission yeast, Schizosaccharomyces pombe, by systematically measuring the phenotypes associated with pairs of mutations. This high-density, quantitative genetic interaction map focused on various aspects of chromosome function, including transcription regulation and DNA repair/replication. The E-MAP uncovered a previously unidentified component of the RNA interference (RNAi) machinery (rsh1) and linked the RNAi pathway to several other biological processes. Comparison of the S. pombe E-MAP to an analogous genetic map from the budding yeast revealed that, whereas negative interactions were conserved between genes involved in similar biological processes, positive interactions and overall genetic profiles between pairs of genes coding for physically associated proteins were even more conserved. Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially.</description><subject>Biological and medical sciences</subject><subject>Biological evolution</subject><subject>Cellular biology</subject><subject>Chromatin</subject><subject>DNA</subject><subject>DNA Repair</subject><subject>DNA Replication</subject><subject>Environmental conservation</subject><subject>Epistasis, Genetic</subject><subject>Evolutionary genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Gene Regulatory Networks</subject><subject>Genes</subject><subject>Genes, Fungal</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype & phenotype</subject><subject>Histones</subject><subject>Histones - metabolism</subject><subject>Human genetics</subject><subject>Molecular biology</subject><subject>Mutation</subject><subject>Quantitative genetics</subject><subject>Research Article</subject><subject>RNA Interference</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomycetales</subject><subject>Schizosaccharomyces - genetics</subject><subject>Schizosaccharomyces - metabolism</subject><subject>Schizosaccharomyces pombe Proteins - genetics</subject><subject>Schizosaccharomyces pombe Proteins - metabolism</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1rFDEYh4Modq2ePamDoJ7G5mPyMRdBlq4KLYLagwcJmUyyZplNtnlnVvrfm2WHWj14Ci_P8_5I8kPoKcFvCaHiDGxw0boyCCpwew8tCG553VLM7qMFxkzUCkt-gh4BbDAurGUP0QlRiigmmgX6sUwRXN6bMaRYmdhXX9yvkENcV8lXqynaAzBDdZn6aXBQ8N6ZwfVVd1P06nwXYDQQoLo0uyrEahUADlHfnYHxMXrgzQDuyXyeoqvV-bflx_ri84dPy_cXtRWUjrVvqWeeW0WoZB33lKrOOmFbT0njSK8c4dR0UnhpCcO-cdw0VvXK-qZtsGen6N0xdzd1W9dbF8dsBr3LYWvyjU4m6L9JDD_1Ou01lZxRTkrAmzkgp-vJwai3AawbBhNdmkDLhpGmUUIU8_V_TdEKSSmTRXz5j7hJUy5fCZoSxlspJC7S2VGyOQFk52_vTLA-NKznhvXccNl4fvepf_y50iK8mgUD1gw-m2gD3HoUK8wl5sV7dvQ2MKZ8h5OGY37gL47cm6TNOpeMq6-FMkw4J4RL9hsd48Nk</recordid><startdate>20081017</startdate><enddate>20081017</enddate><creator>Roguev, Assen</creator><creator>Bandyopadhyay, Sourav</creator><creator>Zofall, Martin</creator><creator>Zhang, Ke</creator><creator>Fischer, Tamas</creator><creator>Collins, Sean R</creator><creator>Qu, Hongjing</creator><creator>Shales, Michael</creator><creator>Park, Han-Oh</creator><creator>Hayles, Jacqueline</creator><creator>Hoe, Kwang-Lae</creator><creator>Kim, Dong-Uk</creator><creator>Ideker, Trey</creator><creator>Grewal, Shiv I</creator><creator>Weissman, Jonathan S</creator><creator>Krogan, Nevan J</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081017</creationdate><title>Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast</title><author>Roguev, Assen ; Bandyopadhyay, Sourav ; Zofall, Martin ; Zhang, Ke ; Fischer, Tamas ; Collins, Sean R ; Qu, Hongjing ; Shales, Michael ; Park, Han-Oh ; Hayles, Jacqueline ; Hoe, Kwang-Lae ; Kim, Dong-Uk ; Ideker, Trey ; Grewal, Shiv I ; Weissman, Jonathan S ; Krogan, Nevan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-f92f3f5c81273b5f228bce6c9f214e1d8e152ab76f7c130f4e5a4c8d8cf4940f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Biological evolution</topic><topic>Cellular biology</topic><topic>Chromatin</topic><topic>DNA</topic><topic>DNA Repair</topic><topic>DNA Replication</topic><topic>Environmental conservation</topic><topic>Epistasis, Genetic</topic><topic>Evolutionary genetics</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5900), p.405-410 |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Biological and medical sciences Biological evolution Cellular biology Chromatin DNA DNA Repair DNA Replication Environmental conservation Epistasis, Genetic Evolutionary genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Gene Regulatory Networks Genes Genes, Fungal Genetics of eukaryotes. Biological and molecular evolution Genotype & phenotype Histones Histones - metabolism Human genetics Molecular biology Mutation Quantitative genetics Research Article RNA Interference Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomycetales Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism Yeast Yeasts |
| title | Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast |
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