dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

The dynamin-related guanosine triphosphatase Drp1 mediates the division of mitochondria and peroxisomes. To understand the in vivo function of Drp1, complete and tissue-specific mouse knockouts of Drp1 were generated. Drp1-null mice die by embryonic day 11.5. This embryonic lethality is not likely c...

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Veröffentlicht in:	The Journal of cell biology 2009-09, Vol.186 (6), p.805-816
Hauptverfasser:	Wakabayashi, Junko, Zhang, Zhongyan, Wakabayashi, Nobunao, Tamura, Yasushi, Fukaya, Masahiro, Kensler, Thomas W, Iijima, Miho, Sesaki, Hiromi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism Animals Antibodies Apoptosis Brain Cells, Cultured Cellular biology Cerebellum Cerebellum - embryology Cerebellum - enzymology Cerebellum - ultrastructure Cytochromes Dynamins Embryology Embryos Fibroblasts - enzymology Fibroblasts - ultrastructure Gestational Age Giant cells Giant Cells - enzymology Giant Cells - ultrastructure GTP Phosphohydrolases - deficiency GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitochondria Mitochondria - enzymology Mitochondria - ultrastructure Mitochondrial Size Myocytes, Cardiac - enzymology Myocytes, Cardiac - ultrastructure Neurons Organelle Shape Organogenesis Peroxisomes Peroxisomes - enzymology Peroxisomes - ultrastructure Purkinje Cells - diagnostic imaging Purkinje Cells - enzymology Rodents Trophoblasts - enzymology Trophoblasts - ultrastructure Ultrasonography
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