Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype: The MIDIA study
OBJECTIVE: To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. RESEARCH DESIGN AND METHODS: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 8...
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| Veröffentlicht in: | Diabetes care 2009-10, Vol.32 (10), p.1904-1906 |
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| creator | Rasmussen, Trond Stene, Lars C Samuelsen, Sven O Cinek, Ondrej Wetlesen, Turid Torjesen, Peter A Rønningen, Kjersti S |
| description | OBJECTIVE: To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. RESEARCH DESIGN AND METHODS: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type 1 diabetes (islet autoimmunity). RESULTS: Thirty-six children developed islet autoimmunity, of whom 10 developed type 1 diabetes. Both maternal BMI greater-than-or-equal30 kg/m² before pregnancy and maternal weight gain greater-than-or-equal15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. CONCLUSIONS: Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type 1 diabetes. |
| doi_str_mv | 10.2337/dc09-0663 |
| format | Article |
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RESEARCH DESIGN AND METHODS: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type 1 diabetes (islet autoimmunity). RESULTS: Thirty-six children developed islet autoimmunity, of whom 10 developed type 1 diabetes. Both maternal BMI greater-than-or-equal30 kg/m² before pregnancy and maternal weight gain greater-than-or-equal15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. CONCLUSIONS: Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type 1 diabetes.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc09-0663</identifier><identifier>PMID: 19592628</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Autoantibodies ; Autoantibodies - immunology ; Autoimmunity ; Biological and medical sciences ; Birth order ; Body Mass Index ; Children & youth ; Diabetes ; Diabetes Mellitus - genetics ; Diabetes Mellitus - immunology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Genetic aspects ; Genotype ; Genotype & phenotype ; Gestational Age ; HLA Antigens - genetics ; HLA-DQ Antigens - genetics ; HLA-DR3 Antigen - genetics ; HLA-DR4 Antigen - genetics ; Humans ; Infant, Newborn ; Insulin - immunology ; Measurement errors ; Medical sciences ; Metabolic diseases ; Miscellaneous ; Obesity ; Original Research ; Pregnancy ; Pregnant women ; Public health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology ; Studies ; Type 1 diabetes ; Weight Gain - physiology</subject><ispartof>Diabetes care, 2009-10, Vol.32 (10), p.1904-1906</ispartof><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 American Diabetes Association</rights><rights>Copyright American Diabetes Association Oct 2009</rights><rights>2009 by the American Diabetes Association. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21997788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19592628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasmussen, Trond</creatorcontrib><creatorcontrib>Stene, Lars C</creatorcontrib><creatorcontrib>Samuelsen, Sven O</creatorcontrib><creatorcontrib>Cinek, Ondrej</creatorcontrib><creatorcontrib>Wetlesen, Turid</creatorcontrib><creatorcontrib>Torjesen, Peter A</creatorcontrib><creatorcontrib>Rønningen, Kjersti S</creatorcontrib><title>Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype: The MIDIA study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE: To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. RESEARCH DESIGN AND METHODS: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type 1 diabetes (islet autoimmunity). RESULTS: Thirty-six children developed islet autoimmunity, of whom 10 developed type 1 diabetes. Both maternal BMI greater-than-or-equal30 kg/m² before pregnancy and maternal weight gain greater-than-or-equal15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. CONCLUSIONS: Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type 1 diabetes.</description><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Birth order</subject><subject>Body Mass Index</subject><subject>Children & youth</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes Mellitus - immunology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Gestational Age</subject><subject>HLA Antigens - genetics</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DR3 Antigen - genetics</subject><subject>HLA-DR4 Antigen - genetics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Insulin - immunology</subject><subject>Measurement errors</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Original Research</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Public health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology</subject><subject>Studies</subject><subject>Type 1 diabetes</subject><subject>Weight Gain - physiology</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkt9u0zAUxiMEYqNwwQuABULckOHYTuJwgZS10FZqRQWbdhm5znHqkdoldib1PXkgXFqqDVW-sOTz8_edf1H0MsEXhNL8Yy1xEeMso4-i86SgaZymjD-OznHCijgtCnIWPXPuFmPMGOdPo7OkSAuSEX4e_Z4LD50RLbqcT9ElKNsBWnTQGGHk9gM6hm9ANyuPxkIbNOo7bZr7mDA1-q7dT2QVWkDntPNgPFpYp72-036LgjCa963XmxbQSIsleHBx6ZyVOnjUqOy9Fcbrpa01OBRshivd1h0YdKP9CvkVoEnIIf7rM5mVaAzG-u0GPqGrEJtPR9MSOd_X2-fREyVaBy8O9yC6_vrlajiJZ9_G02E5ixVLEx8DXoJQULNCJiIlOFOY0qTmNeYyT4WElFNFuJKMpWwpAWiucC4YKQgmfMnoIPq81930yzXUMpTcibbadHotum1lha4eRoxeVY29q0iekoLuBN4fBDr7qwfnq7V2EtpWGLC9q3JKw_hCVoF88x95a_vdYFxFCMWU5flO7u0eakQLlTbKBle5k6xKkmCacRrWYxDFJ6gGDIQUrQGlw_MD_uIEH04Nay1Pfnh1vy3HfvzbugC8OwDCSdGqLiyRdkeOJEWR53zHvd5zSthKNF1grn8QnFCcZDxjeUL_AMTC73s</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Rasmussen, Trond</creator><creator>Stene, Lars C</creator><creator>Samuelsen, Sven O</creator><creator>Cinek, Ondrej</creator><creator>Wetlesen, Turid</creator><creator>Torjesen, Peter A</creator><creator>Rønningen, Kjersti S</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091001</creationdate><title>Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype: The MIDIA study</title><author>Rasmussen, Trond ; Stene, Lars C ; Samuelsen, Sven O ; Cinek, Ondrej ; Wetlesen, Turid ; Torjesen, Peter A ; Rønningen, Kjersti S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f451t-e0beafed49c1a5206f0331d8d08c75ace583f28fc4454bcee37f07a4292028b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Birth order</topic><topic>Body Mass Index</topic><topic>Children & youth</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes Mellitus - immunology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Gestational Age</topic><topic>HLA Antigens - genetics</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DR3 Antigen - genetics</topic><topic>HLA-DR4 Antigen - genetics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Insulin - immunology</topic><topic>Measurement errors</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Original Research</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Public health</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology</topic><topic>Studies</topic><topic>Type 1 diabetes</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, Trond</creatorcontrib><creatorcontrib>Stene, Lars C</creatorcontrib><creatorcontrib>Samuelsen, Sven O</creatorcontrib><creatorcontrib>Cinek, Ondrej</creatorcontrib><creatorcontrib>Wetlesen, Turid</creatorcontrib><creatorcontrib>Torjesen, Peter A</creatorcontrib><creatorcontrib>Rønningen, Kjersti S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, Trond</au><au>Stene, Lars C</au><au>Samuelsen, Sven O</au><au>Cinek, Ondrej</au><au>Wetlesen, Turid</au><au>Torjesen, Peter A</au><au>Rønningen, Kjersti S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype: The MIDIA study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>32</volume><issue>10</issue><spage>1904</spage><epage>1906</epage><pages>1904-1906</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE: To assess whether maternal BMI before pregnancy and weight gain during pregnancy predicted the risk of islet autoimmunity in genetically susceptible children. RESEARCH DESIGN AND METHODS: Of 46,939 newborns screened for the high-risk HLA genotype DR4-DQ8/DR3-DQ2, 1,003 were positive and 885 were followed with serial blood samples tested for autoantibodies to insulin, GAD, and insulinoma-associated protein 2 (IA2). The end point was defined as repeated positivity for two or three autoantibodies or the onset of type 1 diabetes (islet autoimmunity). RESULTS: Thirty-six children developed islet autoimmunity, of whom 10 developed type 1 diabetes. Both maternal BMI greater-than-or-equal30 kg/m² before pregnancy and maternal weight gain greater-than-or-equal15 kg predicted the increased risk of islet autoimmunity (hazard ratio [HR] 2.5, P = 0.023, and HR 2.5, P = 0.015, respectively), independent of maternal diabetes. CONCLUSIONS: Maternal weight may predict risk of islet autoimmunity in offspring with a high genetic susceptibility for type 1 diabetes.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>19592628</pmid><doi>10.2337/dc09-0663</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0149-5992 |
| ispartof | Diabetes care, 2009-10, Vol.32 (10), p.1904-1906 |
| issn | 0149-5992 1935-5548 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Autoantibodies Autoantibodies - immunology Autoimmunity Biological and medical sciences Birth order Body Mass Index Children & youth Diabetes Diabetes Mellitus - genetics Diabetes Mellitus - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genetic aspects Genotype Genotype & phenotype Gestational Age HLA Antigens - genetics HLA-DQ Antigens - genetics HLA-DR3 Antigen - genetics HLA-DR4 Antigen - genetics Humans Infant, Newborn Insulin - immunology Measurement errors Medical sciences Metabolic diseases Miscellaneous Obesity Original Research Pregnancy Pregnant women Public health Public health. Hygiene Public health. Hygiene-occupational medicine Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology Studies Type 1 diabetes Weight Gain - physiology |
| title | Maternal BMI Before Pregnancy, Maternal Weight Gain During Pregnancy, and Risk of Persistent Positivity for Multiple Diabetes-Associated Autoantibodies in Children With the High-Risk HLA Genotype: The MIDIA study |
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