Inducible Expression of Active Protein Phosphatase-1 Inhibitor-1 Enhances Basal Cardiac Function and Protects Against Ischemia/Reperfusion Injury

Ischemic heart disease, which remains the leading cause of morbidity and mortality in the Western world, is invariably characterized by impaired cardiac function and disturbed Ca homeostasis. Because enhanced inhibitor-1 (I-1) activity has been suggested to preserve Ca cycling, we sought to define w...

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Veröffentlicht in:	Circulation research 2009-04, Vol.104 (8), p.1012-1020
Hauptverfasser:	Nicolaou, Persoulla, Rodriguez, Patricia, Ren, Xiaoping, Zhou, Xiaoyang, Qian, Jiang, Sadayappan, Sakthivel, Mitton, Bryan, Pathak, Anand, Robbins, Jeffrey, Hajjar, Roger J, Jones, Keith, Kranias, Evangelia G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Calcium Signaling Calcium-Binding Proteins - metabolism Cardiology. Vascular system Disease Models, Animal Endoplasmic Reticulum - metabolism Fundamental and applied biological sciences. Psychology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Medical sciences Mice Mice, Transgenic Mutation Myocardial Contraction Myocardial Infarction - enzymology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology Myocardium - pathology Necrosis Phosphorylation Proteomics Recovery of Function Sarcoplasmic Reticulum - metabolism Stress, Physiological Time Factors Up-Regulation Ventricular Function, Left Vertebrates: cardiovascular system
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