NVP-BEZ235, A Novel Dual PI3K/mTOR Inhibitor, Elicits Multifaceted Antitumor Activities in Human Gliomas

Aberrant genetic alternations in human gliomas such as amplification of EGFR , mutation and/or deletion of tumor suppressor gene PTEN , and mutations of PIK3CA contribute to constitutive activation of the PI3K pathway. We investigated the potential anti-tumor activity of NVP-BEZ235, which is a novel...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-08, Vol.8 (8), p.2204-2210
Hauptverfasser:	Liu, Ta-Jen, Koul, Dimpy, LaFortune, Tiffany, Tiao, Ningyi, Shen, Rui Jun, Maira, Sauveur-Michel, Garcia-Echevrria, Carlos, Alfred Yung, W. K.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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