Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1

: Free‐radical generation is one of the primary causes of myocardial ischemia/reperfusion (I/R) injury. Melatonin is an efficient free‐radical scavenger and induces the expression of antioxidant enzymes. We have previously shown that melatonin can prevent free‐radical‐induced myocardial injury. To...

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Veröffentlicht in:	Journal of pineal research 2009-03, Vol.46 (2), p.235-241
Hauptverfasser:	Chen, Zhongyi, Chua, Chu C., Gao, Jinping, Chua, Kao-Wei, Ho, Ye-Shih, Hamdy, Ronald C., Chua, Balvin H. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences Cardiology. Vascular system free-radical scavenger Fundamental and applied biological sciences. Psychology glutathione peroxidase Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Heart Medical sciences melatonin Melatonin - pharmacology Mice Mice, Knockout myocardial reperfusion injury Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocarditis. Cardiomyopathies Myocardium - metabolism Myocytes, Cardiac - metabolism Vertebrates: endocrinology
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