Heparin-induced circular dichroism of chloroquine

Circular dichroism (CD) and UV/Visible absorption (UV/Vis) spectroscopy techniques were used to investigate the interaction between heparin and chloroquine, an antimalarial drug that has shown potential as an anti-prion agent. CD spectra of rac-chloroquine upon addition of heparin provide evidence o...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-10, Vol.388 (1), p.28-30
Hauptverfasser:	Stanley, F.E., Warner, A.M., Gutierrez, S.M., Stalcup, A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Chloroquine Chloroquine - chemistry Chloroquine - metabolism Chloroquine - pharmacology Chondroitin sulfate Circular Dichroism Glucosamine - chemistry Glucosamine - metabolism Glycosaminoglycan Heparin Heparin - chemistry Heparin - metabolism Humans Induced circular dichroism Prion Prion Diseases - metabolism Prions - antagonists & inhibitors Spectrophotometry, Ultraviolet
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