Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

T cells develop in the thymus through positive and negative selection, which are responsible for shaping the T cell receptor (TCR) repertoire. To elucidate the molecular mechanisms involved in selection remains an area of intense interest. Here, we identified and characterized a gene product Gasp (G...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-09, Vol.106 (38), p.16345-16350
Hauptverfasser:	Patrick, Michael S, Oda, Hiroyo, Hayakawa, Kunihiro, Sato, Yoshinori, Eshima, Koji, Kirikae, Teruo, Iemura, Shun-ichiro, Shirai, Mutsunori, Abe, Takaya, Natsume, Tohru, Sasazuki, Takehiko, Suzuki, Harumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Blotting, Western CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line Cell lines Cytosol - metabolism Flow Cytometry Gene Expression Genes Humans Immunophenotyping Immunoprecipitation Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Negative selection Phenotypes Positive selection Proteins Proteins - genetics Proteins - immunology Proteins - metabolism Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal transduction Spleen - cytology Spleen - immunology Spleen - metabolism T cell antigen receptors T cell receptors T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymocytes Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism
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