ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

Homologous recombination (HR) and non‐homologous end joining (NHEJ) represent distinct pathways for repairing DNA double‐strand breaks (DSBs). Previous work implicated Artemis and ATM in an NHEJ‐dependent process, which repairs a defined subset of radiation‐induced DSBs in G1‐phase. Here, we show th...

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Veröffentlicht in:	The EMBO journal 2009-11, Vol.28 (21), p.3413-3427
Hauptverfasser:	Beucher, Andrea, Birraux, Julie, Tchouandong, Leopoldine, Barton, Olivia, Shibata, Atsushi, Conrad, Sandro, Goodarzi, Aaron A, Krempler, Andrea, Jeggo, Penny A, Löbrich, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins Artemis ataxia telangiectasia Ataxia Telangiectasia Mutated Proteins BRCA2 Protein - metabolism Breast cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded - radiation effects DNA Helicases DNA repair DNA Repair - drug effects DNA Repair Enzymes - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism double-strand breaks EMBO06 EMBO13 Endonucleases Fibroblasts - radiation effects G1 Phase - radiation effects G2 Phase - radiation effects Gamma rays Gene Deletion Genetic recombination HeLa Cells Heterochromatin - metabolism homologous recombination Humans Lesions Molecular biology non-homologous end joining Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Rad51 Recombinase - metabolism Radiation Replication Protein A - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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