Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury
To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy) for warm hepatic ischemia-reperfusion (I/R) injury after total hepatic vascular exclusion (THVE) using a porcine model. Eleven Mexican hairless pigs weighing 22-38 kg were subjected to...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2009-09, Vol.15 (36), p.4571-4575 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Sato, Hiroaki Oshima, Kiyohiro Kobayashi, Katsumi Yamazaki, Hodaka Suto, Yujin Takeyoshi, Izumi |
| description | To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy) for warm hepatic ischemia-reperfusion (I/R) injury after total hepatic vascular exclusion (THVE) using a porcine model.
Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly: the DHP-PMX group (n = 5) underwent DHP-PMX at a flow rate of 80 mL/min for 120 min (beginning 10 min before reperfusion), while the control group did not (n = 6). The rate pressure product (RPP): heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow (HTBF), portal vein blood flow (PVBF), and serum aspartate aminotransferase (AST) levels were compared between the two groups.
RPP and HTBF were significantly (P < 0.05) higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly (P < 0.05) compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly (P < 0.05) lower in the DHP-PMX group 360 min after reperfusion.
DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model. |
| doi_str_mv | 10.3748/wjg.15.4571 |
| format | Article |
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Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly: the DHP-PMX group (n = 5) underwent DHP-PMX at a flow rate of 80 mL/min for 120 min (beginning 10 min before reperfusion), while the control group did not (n = 6). The rate pressure product (RPP): heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow (HTBF), portal vein blood flow (PVBF), and serum aspartate aminotransferase (AST) levels were compared between the two groups.
RPP and HTBF were significantly (P < 0.05) higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly (P < 0.05) compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly (P < 0.05) lower in the DHP-PMX group 360 min after reperfusion.
DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.15.4571</identifier><identifier>PMID: 19777617</identifier><language>eng</language><publisher>United States: Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan%Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan</publisher><subject>Animals ; Aspartate Aminotransferases - blood ; Blood Flow Velocity ; Blood Pressure ; Brief ; Disease Models, Animal ; Female ; Hemoperfusion - methods ; Liver - blood supply ; Liver - physiopathology ; Liver Diseases - physiopathology ; Liver Diseases - therapy ; Male ; Polymyxin B - therapeutic use ; Portal Vein - physiology ; Reperfusion Injury - physiopathology ; Reperfusion Injury - therapy ; Swine ; Treatment Outcome</subject><ispartof>World journal of gastroenterology : WJG, 2009-09, Vol.15 (36), p.4571-4575</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2009 The WJG Press and Baishideng. All rights reserved. 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-b80e1bc9c05c788bd9f2c0dae014acdd0e1ac77e57f09172ffd972ed4c6474543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752003/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752003/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19777617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Hiroaki</creatorcontrib><creatorcontrib>Oshima, Kiyohiro</creatorcontrib><creatorcontrib>Kobayashi, Katsumi</creatorcontrib><creatorcontrib>Yamazaki, Hodaka</creatorcontrib><creatorcontrib>Suto, Yujin</creatorcontrib><creatorcontrib>Takeyoshi, Izumi</creatorcontrib><title>Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy) for warm hepatic ischemia-reperfusion (I/R) injury after total hepatic vascular exclusion (THVE) using a porcine model.
Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly: the DHP-PMX group (n = 5) underwent DHP-PMX at a flow rate of 80 mL/min for 120 min (beginning 10 min before reperfusion), while the control group did not (n = 6). The rate pressure product (RPP): heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow (HTBF), portal vein blood flow (PVBF), and serum aspartate aminotransferase (AST) levels were compared between the two groups.
RPP and HTBF were significantly (P < 0.05) higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly (P < 0.05) compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly (P < 0.05) lower in the DHP-PMX group 360 min after reperfusion.
DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.</description><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure</subject><subject>Brief</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Hemoperfusion - methods</subject><subject>Liver - blood supply</subject><subject>Liver - physiopathology</subject><subject>Liver Diseases - physiopathology</subject><subject>Liver Diseases - therapy</subject><subject>Male</subject><subject>Polymyxin B - therapeutic use</subject><subject>Portal Vein - physiology</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Reperfusion Injury - therapy</subject><subject>Swine</subject><subject>Treatment Outcome</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc-P1CAYhonRuOPqybvpwXgxHflZ2ovJulHXZBMveiaUfswwKdCFdsbxr5fJTFw9EfiePLzwIvSa4DWTvP1w2G3WRKy5kOQJWlFKupq2HD9FK4KxrDtG5RV6kfMOY8qYoM_RFemklA2RK_RwBz5OkOySXQzVwc3baorj0R9_uVB9qp33sXej-w1DZV0PqTJxXHyonJ9S3EOuRrcvp3YJZj4ZtJ3L1mWzBe90neBR7sJuSceX6JnVY4ZXl_Ua_fzy-cftXX3__eu325v72rCmmeu-xUB60xksjGzbfugsNXjQgAnXZhjKVBspQUiLOyKptUMnKQzcNFxywdk1-nj2TkvvYTAQ5qRHNSXndTqqqJ36fxLcVm3iXlEpKMasCN6eBQcdrA4btYtLCiWyKj9eiI41mNCCvbvck-LDAnlWvrwexlEHiEtWjWwaQTku4PszaFLMOYH9m4VgdWry5FVEqFOThX7zb_xH9lId-wNFMp5n</recordid><startdate>20090928</startdate><enddate>20090928</enddate><creator>Sato, Hiroaki</creator><creator>Oshima, Kiyohiro</creator><creator>Kobayashi, Katsumi</creator><creator>Yamazaki, Hodaka</creator><creator>Suto, Yujin</creator><creator>Takeyoshi, Izumi</creator><general>Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan%Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan</general><general>The WJG Press and Baishideng</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20090928</creationdate><title>Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury</title><author>Sato, Hiroaki ; Oshima, Kiyohiro ; Kobayashi, Katsumi ; Yamazaki, Hodaka ; Suto, Yujin ; Takeyoshi, Izumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-b80e1bc9c05c788bd9f2c0dae014acdd0e1ac77e57f09172ffd972ed4c6474543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure</topic><topic>Brief</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Hemoperfusion - methods</topic><topic>Liver - blood supply</topic><topic>Liver - physiopathology</topic><topic>Liver Diseases - physiopathology</topic><topic>Liver Diseases - therapy</topic><topic>Male</topic><topic>Polymyxin B - therapeutic use</topic><topic>Portal Vein - physiology</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Reperfusion Injury - therapy</topic><topic>Swine</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Sato, Hiroaki</creatorcontrib><creatorcontrib>Oshima, Kiyohiro</creatorcontrib><creatorcontrib>Kobayashi, Katsumi</creatorcontrib><creatorcontrib>Yamazaki, Hodaka</creatorcontrib><creatorcontrib>Suto, Yujin</creatorcontrib><creatorcontrib>Takeyoshi, Izumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Hiroaki</au><au>Oshima, Kiyohiro</au><au>Kobayashi, Katsumi</au><au>Yamazaki, Hodaka</au><au>Suto, Yujin</au><au>Takeyoshi, Izumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2009-09-28</date><risdate>2009</risdate><volume>15</volume><issue>36</issue><spage>4571</spage><epage>4575</epage><pages>4571-4575</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To investigate the usefulness of direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX therapy) for warm hepatic ischemia-reperfusion (I/R) injury after total hepatic vascular exclusion (THVE) using a porcine model.
Eleven Mexican hairless pigs weighing 22-38 kg were subjected to THVE for 120 min and then observed for 360 min. The animals were divided into two groups randomly: the DHP-PMX group (n = 5) underwent DHP-PMX at a flow rate of 80 mL/min for 120 min (beginning 10 min before reperfusion), while the control group did not (n = 6). The rate pressure product (RPP): heart rate x end-systolic arterial blood pressure, hepatic tissue blood flow (HTBF), portal vein blood flow (PVBF), and serum aspartate aminotransferase (AST) levels were compared between the two groups.
RPP and HTBF were significantly (P < 0.05) higher in the DHP-PMX group than in the control group 240 and 360 min after reperfusion. PVBF in the DHP-PMX group was maintained at about 70% of the flow before ischemia and differed significantly (P < 0.05) compared to the control group 360 min after reperfusion. The serum AST increased gradually after reperfusion in both groups, but the AST was significantly (P < 0.05) lower in the DHP-PMX group 360 min after reperfusion.
DHP-PMX therapy reduced the hepatic warm I/R injury caused by THVE in a porcine model.</abstract><cop>United States</cop><pub>Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan%Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511,Japan</pub><pmid>19777617</pmid><doi>10.3748/wjg.15.4571</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2009-09, Vol.15 (36), p.4571-4575 |
| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Aspartate Aminotransferases - blood Blood Flow Velocity Blood Pressure Brief Disease Models, Animal Female Hemoperfusion - methods Liver - blood supply Liver - physiopathology Liver Diseases - physiopathology Liver Diseases - therapy Male Polymyxin B - therapeutic use Portal Vein - physiology Reperfusion Injury - physiopathology Reperfusion Injury - therapy Swine Treatment Outcome |
| title | Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury |
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