Introduction of unsaturation into theN-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: Effect on affinity and selectivity

N-n -Octylnicotinium iodide (NONI) and N-n -decylnicotinium iodide (NDNI) are selective nicotinic receptor (nAChR) antagonists mediating nicotine-evoked striatal dopamine (DA) release, and inhibiting [ 3 H]nicotine binding, respectively. This study evaluated effects of introducing unsaturation into...

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Veröffentlicht in:	The AAPS journal 2005-08, Vol.7 (1), p.E201-E217
Hauptverfasser:	Sumithran, Sangeetha P., Crooks, Peter A., Xu, Rui, Zhu, Jun, Deaciuc, Agripina G., Wilkins, Lincoln H., Dwoskin, Linda P.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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