Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse

The discovery and preclinical development of selective dopamine reuptake inhibitors as potential pharmacotherapies for treating cocaine addiction are presented. The studies are based on the hypothesis that a dopamine reuptake inhibitor is expected to partially substitute for cocaine, thus decreasing...

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Veröffentlicht in:	The AAPS journal 2006-03, Vol.8 (1), p.E196-E203
Hauptverfasser:	Carroll, F Ivy, Howard, James L, Howell, Leonard L, Fox, Barbara S, Kuhar, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - metabolism Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors Dopamine Plasma Membrane Transport Proteins - metabolism Dose-Response Relationship, Drug Humans Technology, Pharmaceutical - trends Tropanes - pharmacology Tropanes - therapeutic use
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