Physical chemical stability of warfarin sodium

Crystalline warfarin sodium is an isopropanol clathrate containing 8.3% isopropyl alcohol (IPA) and 0.57% water upon receipt. The hygroscopicity and impact of moisture on IPA status as well as on the stability of the clathrate was studied at different relative humidities. The IPA loss and water upta...

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Veröffentlicht in:	AAPS PharmSci 2001, Vol.3 (1), p.E3-25
Hauptverfasser:	Gao, D, Maurin, M B
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Propanol Calorimetry, Differential Scanning Crystallization Crystallography, X-Ray Drug Stability Solvents Thermogravimetry Warfarin - chemistry Water
Online-Zugang:	Volltext
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