Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

Actin filaments in stereocilia on the surface of inner ear sensory hair cells are continually renewed. Myosin IIIa transports the actin-binding/bundling protein espin to stereocilia tips and cooperates with espin in actin filament elongation. Two proteins implicated in inherited deafness, myosin III...

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Veröffentlicht in:	Nature cell biology 2009-04, Vol.11 (4), p.443-450
Hauptverfasser:	Salles, Felipe T., Merritt, Raymond C., Manor, Uri, Dougherty, Gerard W., Sousa, Aurea D., Moore, Judy E., Yengo, Christopher M., Dosé, Andréa C., Kachar, Bechara
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actin Cytoskeleton - ultrastructure Animals Ankyrin Repeat Biological transport Biomedical and Life Sciences Cancer Research Cell Biology Cellular control mechanisms Chlorocebus aethiops Cilia - metabolism Cilia - ultrastructure COS Cells Developmental Biology Genetic aspects letter Life Sciences Mice Microfilament Proteins - chemistry Microfilament Proteins - metabolism Myosin Myosin Type III - metabolism Physiological aspects Physiology Protein Binding Protein Transport Proteins Pseudopodia - metabolism Pseudopodia - ultrastructure Rats Stem Cells Transfection
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