Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development

Pharmacological inhibitors that block amyloid precursor protein (APP) cleavage and the formation of senile plaques are under development for the treatment of familial Alzheimer's disease. Unfortunately, many inhibitors that block γ-secretase-mediated cleavage of APP also have immunosuppressive...

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