Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes

Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of these genes in sporadic tumour development therefore remains unclear. The study group consi...

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Veröffentlicht in:	Breast cancer research : BCR 2009-01, Vol.11 (4), p.R47-R47
Hauptverfasser:	Stefansson, Olafur Andri, Jonasson, Jon Gunnlaugur, Johannsson, Oskar Thor, Olafsdottir, Kristrun, Steinarsdottir, Margret, Valgeirsdottir, Sigridur, Eyfjord, Jorunn Erla
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis BRCA mutations Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - classification Breast Neoplasms - genetics Breast Neoplasms - pathology Chromosome abnormalities Cluster Analysis Comparative Genomic Hybridization Complications and side effects Female Gene Dosage Gene Expression Profiling Genes, BRCA1 Genes, BRCA2 Genetic aspects Genetic susceptibility Genomic Instability Genotype Health aspects Humans Oligonucleotide Array Sequence Analysis Phenotype Risk factors Sequence Deletion
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