The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

The JNK‐interacting proteins, JIP3 and JIP4, are specific effectors of the small GTP‐binding protein ARF6. The interaction of ARF6–GTP with the second leucine zipper (LZII) domains of JIP3/JIP4 regulates the binding of JIPs to kinesin‐1 and dynactin. Here, we report the crystal structure of ARF6–GTP...

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Veröffentlicht in:	The EMBO journal 2009-09, Vol.28 (18), p.2835-2845
Hauptverfasser:	Isabet, Tatiana, Montagnac, Guillaume, Regazzoni, Karine, Raynal, Bertrand, Khadali, Fatima El, England, Patrick, Franco, Michel, Chavrier, Philippe, Houdusse, Anne, Ménétrey, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry ADP-Ribosylation Factors - chemistry Amino Acid Sequence ARF6 Binding sites Cellular Biology Crystal structure Dimerization Dynactin Complex effector specificity EMBO37 EMBO40 Guanosine Triphosphate - metabolism heterotetramer JIP4 Kinesin - chemistry leucine zipper Life Sciences Membranes Microtubule-Associated Proteins - chemistry Models, Biological Molecular biology Molecular Conformation Molecular Sequence Data Mutagenesis, Site-Directed Mutation Protein Binding Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Proteins Resonance Surface Plasmon Resonance
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