Pyridoxal 5′-phosphate: electrophilic catalyst extraordinaire

Studies of nonenzymatic electrophilic catalysis of carbon deprotonation of glycine show that pyridoxal 5′-phosphate (PLP) strongly enhances the carbon acidity of α-amino acids, but that this is not the overriding mechanistic imperative for cofactor catalysis. Although the fully protonated PLP–glycin...

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Veröffentlicht in:	Current opinion in chemical biology 2009-10, Vol.13 (4), p.475-483
Hauptverfasser:	Richard, John P, Amyes, Tina L, Crugeiras, Juan, Rios, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Humans Molecular Structure Pyridoxal Phosphate - chemistry Pyridoxal Phosphate - metabolism Thermodynamics
Online-Zugang:	Volltext
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