Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

Cripto is a developmental oncoprotein that signals via mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt and Smad2/3 pathways. However, the molecular basis for Cripto coupling to these pathways during embryogenesis and tumor...

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Veröffentlicht in:	Oncogene 2009-06, Vol.28 (24), p.2324-2336
Hauptverfasser:	Kelber, J A, Panopoulos, A D, Shani, G, Booker, E C, Belmonte, J C, Vale, W W, Gray, P C
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activin Activins - pharmacology AKT protein Antibodies - pharmacology Apoptosis Binding proteins Binding sites Biological and medical sciences Blotting, Western Cadherins - metabolism Cancer Cell adhesion Cell Adhesion - drug effects Cell Biology Cell Line Cell Line, Tumor Cell physiology Cell Proliferation - drug effects Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology E-cadherin Embryo cells Embryogenesis Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Gene expression GPI-Linked Proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - immunology Heat-Shock Proteins - metabolism Hsp70 protein Human Genetics Humans Immunoprecipitation Intercellular Signaling Peptides and Proteins Internal Medicine Kinases Luciferases - genetics Luciferases - metabolism MAP kinase Medicine Medicine & Public Health Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microscopy, Confocal Mitogen-Activated Protein Kinases - metabolism Models, Biological Molecular and cellular biology Molecular biology Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncogenes Oncology original-article Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Protein Binding - drug effects Protein kinase Protein kinases Proteins Radioligand Assay RNA, Small Interfering - genetics Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Smad Proteins - metabolism Smad2 protein Smad2 Protein - metabolism Smad3 Protein - metabolism Stem cells Transforming growth factor-b Tumorigenesis
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