A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role in the development of idiopathic pulmonary arterial hypertension (IPAH), whereas a rise in cytosolic Ca2+ concentration triggers PASMC contraction and stimulates PASMC proliferation. Recently, we demonst...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2009-05, Vol.119 (17), p.2313-2322
Hauptverfasser:	YING YU, KELLER, Steve H, THISTLETHWAITE, Patricia A, CHANNICK, Richard N, ROBBINS, Ivan M, LOYD, James E, GHOFRANI, Hossein A, GRIMMINGER, Friedrich, SCHERMULY, Ralph T, CAHALAN, Michael D, RUBIN, Lewis J, YUAN, Jason X.-J, REMILLARD, Carmelle V, SAFRINA, Olga, NICHOLSON, Ann, ZHANG, Shenyuan L, WEIHUA JIANG, VANGALA, Nivruthi, LANDSBERG, Judd W, WANG, Jian-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Cell Proliferation Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Gene Frequency Genetic Predisposition to Disease Genotype Humans Hypertension - etiology Hypertension - genetics Medical sciences Muscle, Smooth, Vascular Myocytes, Smooth Muscle NF-kappa B - genetics NF-kappa B - metabolism Pneumology Polymorphism, Single Nucleotide Promoter Regions, Genetic Pulmonary Artery - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases TRPC Cation Channels - genetics TRPC6 Cation Channel
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