The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT)

Cannabidiol (CBD) is a cannabinoid compound derived from Cannabis Sativa that does not possess high affinity for either the CB1 or CB2 cannabinoid receptors. Similar to other cannabinoids, we demonstrated previously that CBD suppressed interleukin-2 (IL-2) production from phorbol ester plus calcium...

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Veröffentlicht in:	Biochemical pharmacology 2008-09, Vol.76 (6), p.726-737
Hauptverfasser:	Kaplan, Barbara L.F., Springs, Alison E.B., Kaminski, Norbert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AP-1 Biological and medical sciences Cannabidiol - metabolism Cannabidiol - pharmacology Cannabinoid Cannabis sativa Cells, Cultured Dose-Response Relationship, Drug Female Humans Immunoglobulin M - biosynthesis Immunologic Factors - deficiency Immunologic Factors - pharmacology Interferon-gamma Interferon-gamma - immunology Interleukin-2 Interleukin-2 - immunology Jurkat Cells Medical sciences Mice Mice, Inbred C57BL Mice, Knockout NFAT NFATC Transcription Factors - antagonists & inhibitors NFATC Transcription Factors - physiology Pharmacology. Drug treatments Spleen - cytology Spleen - drug effects Spleen - physiology T-Lymphocytes - drug effects T-Lymphocytes - physiology
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