A new type of neuron-specific aminopeptidase NAP-2 in rat brain synaptosomes

A novel neutral aminopeptidase (NAP-2) was found exclusively in the rat central nervous system (CNS). It was separated from the ubiquitous puromycin-sensitive aminopeptidase (PSA) and the neuron-specific aminopeptidase (NAP) by an automated FPLC-aminopeptidase analyzer. The activity of the neuronal...

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Veröffentlicht in:	Neurochemistry international 2008-12, Vol.53 (6), p.317-324
Hauptverfasser:	Hui, Maria, Hui, Koon-Sea
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Aminopeptidases - chemistry Aminopeptidases - isolation & purification Animals Biological and medical sciences Brain - enzymology Brain - ultrastructure Cattle Cell Line, Tumor Cells, Cultured Chickens Chromatography Cytosol - enzymology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Mice Molecular Weight Neurodegeneration Neurology Neuron-specific aminopeptidase Peptides - pharmacology Presynaptic Terminals - enzymology Presynaptic Terminals - ultrastructure Protease Inhibitors - pharmacology Protein Structure, Tertiary - physiology Puromysin-sensitive aminopeptidase Rats Rats, Sprague-Dawley Species Specificity Synaptosomes Tauopathy Vertebrates: nervous system and sense organs
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