A Role for Brain Stress Systems in Addiction
Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. Activation of brain stress systems is hypothesized to be key to the negative emotional state produced by depende...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2008-07, Vol.59 (1), p.11-34 |
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| creator | Koob, George F. |
| description | Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. Activation of brain stress systems is hypothesized to be key to the negative emotional state produced by dependence that drives drug seeking through negative reinforcement mechanisms. This review explores the role of brain stress systems (corticotropin-releasing factor, norepinephrine, orexin [hypocretin], vasopressin, dynorphin) and brain antistress systems (neuropeptide Y, nociceptin [orphanin FQ]) in drug dependence, with emphasis on the neuropharmacological function of extrahypothalamic systems in the extended amygdala. The brain stress and antistress systems may play a key role in the transition to and maintenance of drug dependence once initiated. Understanding the role of brain stress and antistress systems in addiction provides novel targets for treatment and prevention of addiction and insights into the organization and function of basic brain emotional circuitry. |
| doi_str_mv | 10.1016/j.neuron.2008.06.012 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Free E-Journal (出版社公開部分のみ） |
| subjects | Addictions Alcoholism Animals Anxiety Brain - pathology Brain - physiopathology Dopamine Humans Impulsivity Neuropeptides Neurotransmitters Nicotine Rodents Stress, Physiological - pathology Substance-Related Disorders - pathology |
| title | A Role for Brain Stress Systems in Addiction |
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