Inhibition of calpain attenuates encephalitogenicity of MBP-specific T cells

Multiple sclerosis (MS) is a T-cell mediated autoimmune disease of the CNS, possessing both immune and neurodegenerative events that lead to disability. Adoptive transfer (AT) of myelin basic protein (MBP)-specific T cells into naïve female SJL/J mice results in a relapsing-remitting (RR) form of ex...

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Veröffentlicht in:	Journal of neurochemistry 2009-09, Vol.110 (6), p.1895-1907
Hauptverfasser:	Guyton, Mary K, Brahmachari, Saurav, Das, Arabinda, Samantaray, Supriti, Inoue, Jun, Azuma, Mitsuyoshi, Ray, Swapan K, Banik, Naren L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Axons - drug effects Axons - metabolism Axons - pathology Biochemistry Biological and medical sciences Boron Compounds - metabolism Calcium-Binding Proteins - metabolism Calpain - antagonists & inhibitors Calpain - metabolism Cell Survival - drug effects Cell Survival - physiology Cerebrospinal fluid. Meninges. Spinal cord Demyelinating Diseases - diagnosis Demyelinating Diseases - etiology Demyelinating Diseases - pathology Dipeptides - pharmacology Disease Models, Animal DNA Fragmentation - drug effects Dose-Response Relationship, Drug encephalitogenicity Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology experimental autoimmune encephalomyelitis Female Immune system In Situ Nick-End Labeling - methods inflammation L-Lactate Dehydrogenase - metabolism Lymphocytes Medical sciences Mice Multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Basic Protein - biosynthesis myelin basic protein-specific T cells Nervous system (semeiology, syndromes) Neurology Proteins Statistics, Nonparametric T-Lymphocytes - drug effects T-Lymphocytes - immunology Time Factors
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