Suppression of Protein Phosphatase 2 Differentially Modulates VEGF- and FGF2-Induced Signaling in Ovine Fetoplacental Artery Endothelial Cells

Abstract Vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) elicit cellular responses via activation of protein kinases and phosphatases. We have reported that the MEK1/2/ERK1/2 and PI3K/AKT1 pathways are critical for VEGF- and FGF2-stimulated ovine fetoplacental artery...

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Veröffentlicht in:	Placenta (Eastbourne) 2009-10, Vol.30 (10), p.907-913
Hauptverfasser:	Song, Y, Wang, K, Chen, D.-b, Magness, R.R, Zheng, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - cytology Biological and medical sciences Catalysis Cell Proliferation - drug effects Cells, Cultured Embryology: invertebrates and vertebrates. Teratology Endothelial cell Endothelial Cells - drug effects Endothelial Cells - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Female Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Internal Medicine Nitric Oxide Synthase Type III - metabolism Obstetrics and Gynecology p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Placenta Placenta - blood supply Placenta - cytology Pregnancy Protein Isoforms - metabolism Protein Phosphatase 2 - deficiency Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics Sheep Signal Transduction - drug effects Signal Transduction - physiology Signaling transduction Vascular Endothelial Growth Factor A - pharmacology
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