Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress

Besides its role in translation and ribosome maturation, human ribosomal protein S3 (hS3) is implicated in DNA damage recognition as reflected by its affinity for abasic sites and 7,8-dihydro-8-oxoguanine (8-oxoG) residues in DNA in vitro. Here, we demonstrate that hS3 is capable of carrying out bot...

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Veröffentlicht in:	DNA repair 2007-10, Vol.6 (10), p.1453-1462
Hauptverfasser:	Yadavilli, Sridevi, Hegde, Vijay, Deutsch, Walter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Base excision repair Base Sequence Biological and medical sciences Cell Line DNA Damage DNA Primers ERK Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Genotoxic stress Growth, nutrition, cell differenciation Humans Microbiology Molecular and cellular biology Molecular genetics Mutagenesis, Site-Directed Mutagenesis. Repair Mutagens - toxicity Nuclear translocation Phosphorylation Protein Transport Ribosomal protein S3 Ribosomal Proteins - genetics Ribosomal Proteins - metabolism
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