The Electrocortical Effects of Enflurane: Experiment and Theory

High concentrations of enflurane will induce a characteristic electroencephalogram pattern consisting of periods of suppression alternating with large short paroxysmal epileptiform discharges (PEDs). In this study, we compared a theoretical computer model of this activity with real local field poten...

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Veröffentlicht in:	Anesthesia and analgesia 2009-10, Vol.109 (4), p.1253-1262
Hauptverfasser:	Sleigh, James W., Vizuete, Jeannette A., Voss, Logan, Steyn-Ross, Alistair, Steyn-Ross, Moira, Marcuccilli, Charles J., Hudetz, Anthony G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - toxicity Animals Biological and medical sciences Computer Simulation Dose-Response Relationship, Drug Electroencephalography Enflurane - toxicity Inhibitory Postsynaptic Potentials Male Medical sciences Models, Neurological Rats Rats, Sprague-Dawley Reproducibility of Results Seizures - chemically induced Seizures - physiopathology Time Factors Visual Cortex - drug effects Visual Cortex - physiopathology
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