A key role for corticotropin-releasing factor in alcohol dependence

Recent data indicate that alcohol dependence induces long-term neuroadaptations that recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by relief of negative emotionality. A key mechanism in this transition to negative reinforcement is a recruitment of corticotro...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2007-08, Vol.30 (8), p.399-406
Hauptverfasser:	Heilig, Markus, Koob, George F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Affect - drug effects Affect - physiology Alcohol-Related Disorders - metabolism Alcoholism Alcoholism and acute alcohol poisoning Amygdala - metabolism Animals Behavior, Addictive - metabolism Biological and medical sciences Brain Corticotropin-Releasing Hormone - metabolism Emotions Ethanol - pharmacology Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Hormones Humans Medical sciences Neurology Reward Toxicology Vertebrates: nervous system and sense organs
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