A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring
To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring. Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood po...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2009-09, Vol.15 (35), p.4423-4428 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Kotze, Lorete Maria da Silva Brambila Rodrigues, Ana Paula Kotze, Luiz Roberto Nisihara, Renato Mitsunori |
| description | To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring.
Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea.
Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings.
The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring. |
| doi_str_mv | 10.3748/wjg.15.4423 |
| format | Article |
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Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea.
Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings.
The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.15.4423</identifier><identifier>PMID: 19764094</identifier><language>eng</language><publisher>United States: Gastroenterology and Endoscopy Services, Cajuru Hospital, Pontifical Catholic University of Paraná CEP 80240-220, Curitiba, Paraná Brazil%Evangelical University and Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná CEP 80240-220, Curitiba, Paraná Brazil</publisher><subject>Antibodies - blood ; Brazil ; Brief ; Case-Control Studies ; Celiac Disease - diagnosis ; Celiac Disease - diet therapy ; Celiac Disease - immunology ; Diet, Gluten-Free - adverse effects ; Enzyme-Linked Immunosorbent Assay ; Family ; Female ; Humans ; Immunoglobulin A - blood ; Male ; Middle Aged ; Point-of-Care Systems - standards ; Reagent Kits, Diagnostic ; Transglutaminases - blood ; Transglutaminases - immunology ; Young Adult</subject><ispartof>World journal of gastroenterology : WJG, 2009-09, Vol.15 (35), p.4423-4428</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2009 The WJG Press and Baishideng. All rights reserved. 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-3cca422e8184a7e59c852a8fde41a22940cb26324e82802990688dba1aca4ed3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747063/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747063/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19764094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotze, Lorete Maria da Silva</creatorcontrib><creatorcontrib>Brambila Rodrigues, Ana Paula</creatorcontrib><creatorcontrib>Kotze, Luiz Roberto</creatorcontrib><creatorcontrib>Nisihara, Renato Mitsunori</creatorcontrib><title>A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring.
Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea.
Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings.
The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring.</description><subject>Antibodies - blood</subject><subject>Brazil</subject><subject>Brief</subject><subject>Case-Control Studies</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - diet therapy</subject><subject>Celiac Disease - immunology</subject><subject>Diet, Gluten-Free - adverse effects</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Family</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Point-of-Care Systems - standards</subject><subject>Reagent Kits, Diagnostic</subject><subject>Transglutaminases - blood</subject><subject>Transglutaminases - immunology</subject><subject>Young Adult</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1vGyEQxVGVqnHTnnqPOORWrQsDa-ASKYn6JUXqJXc0Zmc3WGvWgnXS9q8vlqMkvQyI95vHwGPskxRLZbT98rgZlrJdag3qDVsASNeA1eKELaQQpnEKzCl7X8pGCFCqhXfsVDqz0sLpBctX_Drj3zhGTJx-7yhHSoH41PP5nnihsW4ypjKM-xm3MWGhZl1Lx2cqM--nzAPV7sC7WKgKPBxKH1MX08AxdVWgmW-nFOcp17MP7G2PY6GPT-sZu_v29e7mR3P76_vPm6vbJihj5kaFgBqArLQaDbUu2BbQ9h1piQBOi7CGlQJNFqwA58TK2m6NEmsfdeqMXR5td_v1lrpAqb5j9Lsct5j_-Amj_19J8d4P04MHo41YqWpwcTR4xNRjGvxm2udUJ_b1x0EIp1ohZcU-H7GQp1Iy9c9XSOEPAR1wL1t_CKjS56-nemGfElH_AHZzjms</recordid><startdate>20090921</startdate><enddate>20090921</enddate><creator>Kotze, Lorete Maria da Silva</creator><creator>Brambila Rodrigues, Ana Paula</creator><creator>Kotze, Luiz Roberto</creator><creator>Nisihara, Renato Mitsunori</creator><general>Gastroenterology and Endoscopy Services, Cajuru Hospital, Pontifical Catholic University of Paraná CEP 80240-220, Curitiba, Paraná Brazil%Evangelical University and Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná CEP 80240-220, Curitiba, Paraná Brazil</general><general>The WJG Press and Baishideng</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20090921</creationdate><title>A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring</title><author>Kotze, Lorete Maria da Silva ; 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Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea.
Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings.
The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring.</abstract><cop>United States</cop><pub>Gastroenterology and Endoscopy Services, Cajuru Hospital, Pontifical Catholic University of Paraná CEP 80240-220, Curitiba, Paraná Brazil%Evangelical University and Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná CEP 80240-220, Curitiba, Paraná Brazil</pub><pmid>19764094</pmid><doi>10.3748/wjg.15.4423</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibodies - blood Brazil Brief Case-Control Studies Celiac Disease - diagnosis Celiac Disease - diet therapy Celiac Disease - immunology Diet, Gluten-Free - adverse effects Enzyme-Linked Immunosorbent Assay Family Female Humans Immunoglobulin A - blood Male Middle Aged Point-of-Care Systems - standards Reagent Kits, Diagnostic Transglutaminases - blood Transglutaminases - immunology Young Adult |
| title | A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring |
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