Diarylethynyl Amides That Recognize the Parallel Conformation of Genomic Promoter DNA G-Quadruplexes

We report bis-phenylethynyl amide derivatives as a potent G-quadruplex binding small molecule scaffold. The amide derivatives were efficiently prepared in 3 steps by employing Sonogashira coupling, ester hydrolysis and a chemoselective amide coupling. Ligand-quadruplex recognition has been evaluated...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-11, Vol.130 (47), p.15950-15956
Hauptverfasser:	Dash, Jyotirmayee, Shirude, Pravin S, Hsu, Shang-Te Danny, Balasubramanian, Shankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Circular Dichroism DNA - chemistry DNA - genetics G-Quadruplexes Genome - genetics Ligands Magnetic Resonance Spectroscopy Nucleic Acid Denaturation Promoter Regions, Genetic - genetics Surface Plasmon Resonance Titrimetry
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