C-Terminal Flap Endonuclease (rad27) Mutations: Lethal Interactions With a DNA Ligase I Mutation (cdc9-p) and Suppression by Proliferating Cell Nuclear Antigen (POL30) in Saccharomyces cerevisiae

During lagging-strand DNA replication in eukaryotic cells primers are removed from Okazaki fragments by the flap endonuclease and DNA ligase I joins nascent fragments. Both enzymes are brought to the replication fork by the sliding clamp proliferating cell nuclear antigen (PCNA). To understand the r...

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Veröffentlicht in:	Genetics (Austin) 2009-09, Vol.183 (1), p.63-78
Hauptverfasser:	Karanja, Kenneth K, Livingston, Dennis M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear - genetics Canavanine - pharmacology deoxyribonucleases DNA Ligase ATP DNA Ligases - chemistry DNA Ligases - genetics DNA Ligases - metabolism DNA repair DNA replication DNA-binding proteins Drug Resistance, Fungal - genetics Enzymes Epistasis, Genetic - physiology flap endonuclease Flap Endonucleases - chemistry Flap Endonucleases - genetics Genes, Lethal - physiology Genetic Complementation Test Genetics Investigations mutants Mutation Mutation - physiology Organisms, Genetically Modified Phenotype proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Protein Interaction Domains and Motifs - genetics Protein Structure, Tertiary - genetics Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Suppression, Genetic - physiology
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