A Feed-Forward Loop Involving Protein Kinase Cα and MicroRNAs Regulates Tumor Cell Cycle

Protein kinase Cα (PKCα) has been implicated in cancer, but the mechanism is largely unknown. Here, we show that PKCα promotes head and neck squamous cell carcinoma (SCCHN) by a feed-forward network leading to cell cycle deregulation. PKCα inhibitors decrease proliferation in SCCHN cell lines and xe...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009, Vol.69 (1), p.65-74
Hauptverfasser:	COHEN, Ezra E. W, HONGYAN ZHU, LINGEN, Mark W, MARTIN, Leslie E, KUO, Wen-Liang, CHOI, Eugene A, KOCHERGINSKY, Masha, PARKER, Joel S, CHUNG, Christine H, RICH ROSNER, Marsha
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Medical sciences Pharmacology. Drug treatments Tumors
Online-Zugang:	Volltext
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